“Aiming at the identification of novel targets for preventive and therapeutic strategies against Hepatitis C virus (HCV)-induced liver disease, we focus on the characterization of virus host-interactions and the pathogenesis of HCV infection during the late steps of the HCV life cycle. I’m especially interested in the relationship between HCV and cell host lipids and lipoproteins as well as the regulation of HCV IRES driven translation.”
Dr. Catherine Schuster
Presently, Dr. Schuster’s team is developing a new research axis focusing on the relationship between hepatitis C viral infection and human lipid metabolism at the Inserm unit U1110. Using RNAi and yeast-two-hybrid screens, her group recently discovered key host factors required for the HCV life cycle and in particular, demonstrated the role of apolipoprotein E in hepatitis C virus assembly and export. Current research interests include the molecular characterization of virus-host interactions at the level of lipid metabolism and regulation of HCV genome translation. In 2011, Dr. Schuster became an Inserm research director and since 2013 she is the deputy director of the Inserm research unit U1110. Dr. Schuster was elected a scientific member of the Doctoral School “Vie et Santé” council (ED414) at Strasbourg where she gives lectures at the Master's level. She was appointed deputy head in 2013. Dr. Schuster was an expert for the University of Strasbourg at the CSS 65 and 64 from 2000 to 2011 and is since 2013 a scientific delegate for the AERES “Evaluation Agency for Research and Higher Education”.
Research in her group is supported by Inserm, the Agence Nationale de Recherches sur le Sida, hépatites virales B et C (ANRS), the “Fondation BNP-Paribas”, the IdEx program of the University of Strasbourg.